Th is study use s Pearson correlation test method with SPSS 22.0 for Windows program. Met hods : Observasional, consecutive, 100 people with type 2 diabetes mellitus who is examined in apoprotein B, apoprotein A- I test that calculating the ratio in which ratio are calculated, as well as HOMA - IR in Parahita Clinical Laboratory Surabaya. Purpose: This study aim to determine the correlation between the apoprotein B/apoprotein A-I ratio with HOMA-IR in patients with type 2 diabetes mellitus. It is astrong signifier in predicting heart disease. The apo B/apo A-I ratio represents a balance between LDL cholesterol (atherogenic) and HDL (anti-atherogenic). The apoprotein B/apoprotein A-I ratio is the result of comparisons of apoprotein B (LDL protein constituent ) and apoprotein A-I (HDL protei n constituent). Diabetes mellitus can cause lipid metabolism disorders (dyslipidemia) resulting in an increased level of LDL cholesterol and decreased HDL cholesterol. Homeostatic Model Assessment-Insuline Resistance ( HOMA-IR ) is a c alculation method which function is to measur e the body insulin resistance. Type2 DM is caused by the body cells ’ inability to respond normally to insulin (insulin resistance). Background: Diabetes mellitus (DM) is the seventh leading cause of death in the world (the occuring rate has reached 400 million people).
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